姚志华 裘敏蕾 樊天佑
In order to provide theoretical basis for the clinical treatment of osteoarthritis, the mechanism of inflammatory cytokines in osteoarthritis pain was investigated. A computer-based search of PubMed and China National Knowledge Infrastructure ( CNKI ) database was performed for the related articles with the keywords of “inflammatory cytokines, interleukin, tumor necrosis factor, chemokines, osteoarthritis pain, neuropathic pain and biochemical mechanisms” in English or in Chinese. The literatures related to the mechanism of inflammatory cytokines in osteoarthritis pain were selected. A total of 84 literatures were primarily selected and 42 articles were reviewed according to the inclusion criteria. Osteoarthritis pain is one of the main factors affecting the life quality of the patients, and a variety of abnormal cells of the peripheral and central nervous systems were involved. Inflammatory cytokines played an important role in the pathogenesis of osteoarthritis. The relationship between osteoarthritis pain and common inflammatory cytokines were reviewed in the review, so as to explore the important role of inflammatory cytokines in osteoarthritis pain and provide theoretical basis for the clinical treatment of osteoarthritis.
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