陈松 符培亮 丛锐军 吴宇黎
Objective To review the current research progress of meniscus tissue engineering. Methods Recent literatures concerning meniscus tissue engineering at home and abroad are extensively reviewed, and the current situation and progress are summarized. Results The research of meniscus tissue engineering mainly focuses on the selection of seed cells and their potential of differentiation into chondrocytes, the selection of scaffold materials and their mechanical properties, the mechanisms of action of cytokines in the process of cell culture, the effects of mechanical stimulation on cartilage differentiation and so on. Conclusions Many achievements have been obtained in meniscus tissue engineering. The next study focuses are to find the seed cells more in accordance with the physiological process, easy to culture and with higher chondrogenic differentiation ability, to explore the cytokines that promote seed cells to differentiate into chondrocytes, especially fibrochondrocytes and their mechanisms of action in the process of differentiation, to look for the scaffold materials with strong morphological plasticity, no antigenicity, good degradability, and mechanical properties close to those of the scaffold materials of normal meniscuses.
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